Bow Wow's the fall guy for all of the events in Houston this weekend that didn't follow proper COVID-19 protocols ... according to the rapper himself, who believes the mayor has it out for him.

As we reported ... BW was criticized for drawing a large, mostly unmasked crowd at a club Friday night, and caught the attention of Houston Mayor Sylvester Turner because he had more gigs scheduled the rest of the weekend.

The mayor tweeted Sunday that Bow Wow's scheduled events in Houston were on his radar, adding ... "Other bars/clubs that are operating as restaurants, beyond capacity and social distancing requirements, please expect visits."

Though the mayor cited rising COVID cases and deaths in his city and made it clear "Concerts are not allowed in Houston at this time unless it is virtual," Bow Wow's taking it personally ... griping, "Safe to say the mayor of houston hates my guts."

The rapper says he's skipping town but he can't believe he's getting blamed for the whole weekend, and points out he wasn't the only celeb there over the weekend.

That's true -- as we told you ... Meek Mill and J. Prince Jr. were also at the club with Bow Wow Friday night, and neither seemed to be wearing masks, like most of the crowd.